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Cordyceps Benefits: What the Evidence Says, Dosage and Side Effects (UK)

Cordyceps is a fungus sold mainly as Cordyceps militaris or as CS-4, a lab-grown form of Cordyceps sinensis. Human evidence is small: mostly short exercise trials, including a few in older adults.

Cordyceps Mushrooms: Benefits, Side Effects & Uses

Last updated: October 2026

Cordyceps is a fungus sold mainly as Cordyceps militaris or as CS-4, a lab-grown form of Cordyceps sinensis. Human evidence is small: mostly short exercise trials, including a few in older adults. There are no authorised health claims for cordyceps in Great Britain. Avoid it with blood thinners, in pregnancy and before surgery.

This guide sets out every popular cordyceps benefit claim against the actual studies (who took part, the dose, how long and what happened), then covers cordyceps for men and women, dosage, side effects and who should avoid it, and how to choose a product in the UK.

What is cordyceps?

Cordyceps is a group of fungi. The famous wild form, now usually called Ophiocordyceps sinensis, grows on caterpillar larvae high on the Tibetan plateau and is extremely expensive. Almost all supplements are grown in labs instead, either as a fermented mycelium (often sold as “CS-4”) or as cultivated fruiting bodies of Cordyceps militaris. It isn’t psychoactive and has none of the effects of “magic” mushrooms.

The compounds researchers study most are cordycepin and adenosine (both nucleosides), polysaccharides including beta-glucans, and sterols. Cordyceps species infect insects, not people, so the zombie fungus in TV dramas is fiction.

We don’t sell a cordyceps product. If you’re building a mushroom routine, our Reishi Mushroom Adaptogenic Complex is a different mushroom: a reishi hot chocolate made with reishi mushroom, cocoa, maca and coconut milk. It contains a little natural caffeine from the cacao.

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The FSA’s 10mg a day figure for CBD is precautionary advice rather than a legal limit, set while longer-term safety research continues. At Evopure we think it is a very cautious figure, and many adults use more. If you go above it, increase slowly, and check with your GP or pharmacist first if you take any medication.

Cordyceps sinensis vs militaris

Wild Cordyceps sinensis, now classified as Ophiocordyceps sinensis, is the caterpillar fungus dug up by hand on the Tibetan plateau and in the Himalayas. Demand has made it one of the world’s most valuable biological commodities, and collectors in four countries report harvests falling through overharvesting and a warming climate. Scarcity has also brought counterfeits, so an everyday supplement labelled “Cordyceps sinensis” is almost never the wild mushroom.

Instead, most supplements use one of two lab-grown options. CS-4 is mycelium (the root-like threads) grown by fermentation in tanks; the original CS-4 strain has been identified as a related fungus, Paecilomyces hepiali, and fermented mycelium has a different chemical profile from wild caterpillar fungus. Cordyceps militaris is a separate species whose fruiting bodies (the mushroom itself) are easy to cultivate.

Cordyceps sinensis (CS-4) Cordyceps militaris
How it’s made Fermented mycelium, as wild sinensis is rare Fruiting bodies grown on substrate
Key compounds Adenosine, polysaccharides Higher in cordycepin
Human research Older exercise trials (mixed), many Chinese kidney and lung trials Newer small trials on exercise and immune markers
Cost Moderate Usually the most affordable

Neither has been shown to be better in head-to-head trials. Here’s what the wording on a label usually means:

  • “Cordyceps sinensis” or “CS-4”: almost always fermented mycelium, not the wild fungus.
  • “Cordyceps militaris fruiting body”: the cultivated mushroom itself; look for a stated cordycepin figure.
  • “Mycelium” or “myceliated grain”: may include the grain it was grown on (see how to choose).
  • “Wild” or “Himalayan” caterpillar fungus: very expensive and often faked, so be sceptical of anything cheap.

Could cordyceps infect humans?

No. The fungus in The Last of Us is a fictional, unnamed cordyceps. Its real-life cousins are the “zombie-ant” fungi such as Ophiocordyceps unilateralis, which genuinely do take over carpenter ants: infected ants climb up and clamp their jaws onto a leaf, where they stay fixed long after death. But these fungi are highly specific to their insect hosts, and our body temperature of about 37°C is a strong barrier: when researchers tested about 4,800 fungal strains, most couldn’t grow at mammalian temperatures. Caterpillar fungus mycelium grows best at about 16°C. Supplement cordyceps are different, lab-grown species.

Cordyceps benefits: what the research shows

Most “benefits of cordyceps” lists are built on lab and animal studies. We searched PubMed in October 2026 and read the human trials and reviews behind each popular claim. Here is what they found, with our honest rating of how certain each one is.

Claim Best human study People Length Dose Result Certainty
Exercise and energy Hirsch 2017; Parcell 2004 28 active young adults; 22 trained male cyclists 1 to 3 weeks; 5 weeks 4g a day of a mushroom blend with militaris; 3g a day CS-4 Blend: no change after 1 week, better VO2 max in the 10 who carried on to 3 weeks. Cyclists: no change in fitness or performance Low, mixed
Older adults’ exercise capacity Chen 2010 20 healthy adults aged 50 to 75 12 weeks CS-4, 333mg three times a day (about 1g) Metabolic threshold up 10.5% and ventilatory threshold up 8.5% vs placebo; no change in VO2 max Low (one small pilot)
Recovery after exercise Dewi 2024 14 young adults Single dose 1g C. sinensis before hard interval cycling Muscle biopsies showed faster clearing of exercise damage and earlier stem cell activity Very low (lab markers, one tiny trial)
Blood sugar Ontawong 2024; Farzan 2026 Healthy adults 8 weeks; single dose Militaris drink; 1g militaris extract No change in blood sugar in either trial. Lowering has only been shown in mice Animal only
Kidney health Cochrane review, Zhang 2014 22 trials, 1,746 people with chronic kidney disease Varied C. sinensis preparations alongside usual medical treatment Some better blood and urine markers, but trials were poor quality and no firm conclusions were possible Low
Lungs Yu 2019 review 15 trials, 1,238 people with stable COPD Varied C. sinensis alone or in herbal formulas Possible improvements, but none of the trials were placebo-controlled or high quality Low
Libido and testosterone No good human trial found Mice and cells n/a n/a Raised testosterone in mice; not shown in people Animal and lab only
Brain and focus Farzan 2026 12 active young men Single dose (crossover) 1g militaris extract 30 minutes before a cycling test Faster reaction time after exhausting exercise; accuracy unchanged. Memory claims rest on animal studies Very low
Immune system Kang 2015; Ontawong 2024 79 healthy Korean men; healthy Thai men and women 4 weeks; 8 weeks 1.5g a day militaris; militaris drink with 2.85mg cordycepin Higher natural killer cell activity in blood tests. Neither trial measured colds or infections Low

Our take: cordyceps may give a small lift to exercise capacity in less-trained or older people, but don’t expect a performance boost if you’re already fit. The immune findings are changes in blood tests, not proof of fewer colds. The kidney and lung studies were in people with diagnosed disease, using cordyceps alongside hospital treatment, mostly in China, so they don’t tell you what a supplement does for a healthy adult. Libido, testosterone, blood sugar and memory claims rest almost entirely on animal and lab work.

If you have kidney disease or a lung condition such as COPD, don’t add cordyceps without talking to your specialist. A placebo-controlled trial of militaris capsules in COPD has been planned, which should give a clearer answer. For a wider view of mushrooms and energy, see adaptogens for energy, and for mood and stress, best mushrooms for anxiety.

Cordyceps for men and women

Cordyceps for men

A lot of cordyceps marketing is aimed at men, mostly around stamina, libido and testosterone. Most of the human trials did recruit men (the Korean immune trial, the cyclists and the reaction-time study), but they measured fitness and blood markers, not hormones or sexual function. The testosterone findings come from mice and cell studies, and the Memorial Sloan Kettering Cancer Center notes that whether this happens in humans is unknown.

There is no special dose for men: the trials above used 1 to 4g a day. If low libido, erection problems or tiredness are bothering you, see your GP rather than self-treating, as these can have medical causes worth checking. Our supplements for men over 40 guide covers what is worth taking.

Cordyceps for women

Here is the honest version. There are no authorised health claims for cordyceps, and few trials have looked at women specifically.

  • Exercise and energy: the cyclist and reaction-time studies in our table recruited only men, and the published summaries of the others don’t report results for women separately.
  • Immune markers: the Thai trial is one of the few to report women separately. In this small trial, women who had a militaris drink for 8 weeks showed higher natural killer cell activity than at the start, compared with placebo, but it measured blood markers, not colds or infections.
  • Tiredness: we found no trial of cordyceps for fatigue in women. If you’re tired all the time, see your GP.
  • Fertility, periods and hormones: the claims online rest on cells in a dish, and those point both ways. One study found cordyceps mycelium raised oestradiol production by human ovary cells, while another found cordycepin dampened a key hormone-making protein in the same type of cell. Neither shows what a capsule does in the body, and we found no placebo-controlled trial for menopause, periods or fertility. Our mushrooms for menopause guide covers the animal research.

Don’t take cordyceps if you’re pregnant, trying to conceive or breastfeeding, as its safety isn’t known. We don’t recommend our products during pregnancy or breastfeeding. Avoid it too if you have an autoimmune condition such as lupus or rheumatoid arthritis, or take immunosuppressants, as it may make symptoms flare, and check with your GP or pharmacist if you take a blood thinner, as it may increase bleeding risk.

Cordyceps dosage and how to take it

No official dose has been set for cordyceps. These are the amounts used in the human trials:

Trial Type Dose
Older adults, 12 weeks CS-4 (C. sinensis mycelium) 333mg three times a day (about 1g)
Immune markers, 4 weeks C. militaris 1.5g a day
Trained cyclists, 5 weeks CS-4 3g a day
Active adults, 1 to 3 weeks Mushroom blend with C. militaris 4g a day
Single-dose exercise studies C. militaris extract or C. sinensis 1g, 30 minutes or so before exercise
  • Amount: 1 to 3g a day is typical. Follow the label, as extract strengths vary a lot between products.
  • Extract type matters: a gram of concentrated fruiting-body extract isn’t the same as a gram of whole mycelium powder. Compare products by what’s in them (species, part, beta-glucans), not just grams.
  • Timing: morning or 30 to 60 minutes before exercise. Many people avoid it late in the day.
  • With food: taking it with breakfast can help if it upsets your stomach.
  • Formats: capsules, powders stirred into coffee or smoothies, tea or gummies. See mushroom coffee, mushroom tea and our guide to mushroom gummies, which often contain far less mushroom per serving than the trials used.
  • Start low: begin at the lower end and check with your GP or pharmacist first if you take any medication.

How long does it take to work?

In the longer trials, changes appeared after 3 to 12 weeks, not after a single dose. If you try it, take it daily for at least four weeks and keep a simple note of your energy and training before deciding whether it’s worth continuing.

Side effects and who should avoid it

Cordyceps is generally well tolerated in short trials, and no serious side effects have been reported in them. It isn’t risk-free, though:

  • Common: mild stomach upset, nausea and dry mouth.
  • Allergy: hives, rash, itching or swelling are possible. Stop and get medical help if you have any breathing difficulty or swelling of the face or tongue.
  • Bleeding: lab studies show cordyceps can affect blood platelets, and there is a case report of heavy bleeding after a tooth extraction. Avoid it if you take blood thinners (such as warfarin, apixaban or clopidogrel) or have a bleeding disorder, unless your doctor agrees.
  • Before surgery: stop at least two weeks before planned surgery or dental work, and tell your surgeon or dentist you’ve been taking it.
  • Diabetes medicines: it may add to the effect of insulin or tablets that lower blood sugar. Check with your GP or pharmacist first.
  • Immunosuppressants and autoimmune conditions: because it may stimulate the immune system, avoid it if you take immunosuppressants (for example after a transplant) or have an autoimmune condition such as rheumatoid arthritis, lupus or MS, unless your specialist agrees.
  • Blood cancers: Memorial Sloan Kettering advises people with myeloid-type cancers not to take it, based on animal findings.
  • Pregnancy and breastfeeding: avoid, as safety isn’t known.
  • Children: not for under-18s. All Evopure products are for adults only.
  • Quality: mushrooms can absorb heavy metals from where they grow, so choose a cultivated product tested for contaminants.

On medication? Speak to your GP or pharmacist before taking cordyceps, especially if you take blood thinners, diabetes medicines or immunosuppressants, or have kidney disease.

How to choose a cordyceps supplement in the UK

Cordyceps is sold in the UK as a food supplement. There are no authorised health claims for it on the GB register, so be wary of labels promising stamina, hormones or immunity. Use this checklist:

  • Species named: Cordyceps militaris or Cordyceps sinensis (CS-4). “Cordyceps” on its own isn’t enough.
  • Part used: fruiting body, mycelium, or both. Mycelium grown on grain such as oats or rice is often ground up with the grain, which is mostly starch.
  • Beta-glucan figure: look for a tested beta-glucan percentage. A “polysaccharides” figure can include starch, and lab methods now measure the two separately.
  • Cordycepin: for militaris, a stated cordycepin content makes products easier to compare.
  • Dose per serving: check it is in the range used in trials (1 to 3g of mushroom, or a clearly stated extract equivalent).
  • Lab testing: third-party certificates for heavy metals and microbes, ideally from an ISO 17025 lab.
  • Short ingredients list: watch for added caffeine or stimulants in “energy” blends.

Our best mushroom supplements UK guide explains these label terms in more depth.

Cordyceps vs lion’s mane vs reishi

Cordyceps Lion’s mane Reishi
Used for Energy, exercise Focus, memory Evening calm
Best time Morning, pre-workout Morning Evening

Full comparison: lion’s mane vs reishi vs cordyceps. For the morning focus mushroom, read our lion’s mane guide, and for all the popular mushrooms, see our adaptogenic mushrooms guide.

We don’t currently sell a cordyceps product. For the evening side of a mushroom routine, our Reishi Mushroom Adaptogenic Complex is a reishi hot chocolate with cacao, maca and coconut milk.

Related guides

Sources 32

  1. Chen S et al. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects. J Altern Complement Med, 2010.
  2. Hirsch KR et al. Cordyceps militaris improves tolerance to high-intensity exercise after acute and chronic supplementation. J Diet Suppl, 2017.
  3. Parcell AC et al. Cordyceps sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance. Int J Sport Nutr Exerc Metab, 2004.
  4. Dewi L et al. Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise. Food Funct, 2024.
  5. Farzan H, Koushkie Jahromi M. Acute Cordyceps militaris supplementation and elevated resting oxygen uptake with faster reaction times: a randomized crossover trial. PLoS One, 2026.
  6. Kang HJ et al. Cordyceps militaris enhances cell-mediated immunity in healthy Korean men. J Med Food, 2015.
  7. Ontawong A et al. A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Sci Rep, 2024.
  8. Zhang HW et al. Cordyceps sinensis for treating chronic kidney disease. Cochrane Database Syst Rev, 2014.
  9. Yu X et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: systematic review and meta-analysis. Evid Based Complement Alternat Med, 2019.
  10. Evaluating Cordyceps militaris capsules on post-bronchodilator FEV1 decline in patients with COPD: a study protocol. Front Pharmacol, 2026.
  11. Shi H et al. Metabolic effects of Cordyceps militaris ethanol extract and cordycepin in mice with type 2 diabetes and hyperlipidaemia. Food Funct, 2026.
  12. Huang B et al. Cultured Cordyceps sinensis ameliorates oligoasthenozoospermia by enhancing testosterone production (mouse and cell study). J Agric Food Chem, 2026.
  13. Tancreda G et al. Preclinical evidence of Withania somnifera and Cordyceps spp.: neuroprotective properties for the management of Alzheimer’s disease. Int J Mol Sci, 2025.
  14. Yang EJ et al. An immunomodulatory mushroom, Cordyceps militaris, and its constituents: a review of in vitro/in vivo studies and clinical trials. Phytother Res, 2026.
  15. Shen S et al. Effect of a new skin-lightening cosmetic containing Cordyceps extract in the treatment of melasma: a clinical trial. J Cosmet Dermatol, 2025.
  16. McCleary BV, Draga A. Measurement of beta-glucan in mushrooms and mycelial products. J AOAC Int, 2016.
  17. Hopping KA et al. The demise of caterpillar fungus in the Himalayan region due to climate change and overharvesting. PNAS, 2018.
  18. Meng G et al. Chinese cordyceps products, geographic traceability and authenticity assessment. Crit Rev Biotechnol, 2025.
  19. He Z et al. The conservation crisis of Ophiocordyceps sinensis: strategies, challenges and sustainable future of artificial cultivation. J Fungi, 2025.
  20. Yao L et al. Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis (animal and cell study, cited for the strain name). J Ethnopharmacol, 2026.
  21. Ko YF et al. Isolation, culture and characterization of Hirsutella sinensis mycelium from caterpillar fungus fruiting body. PLoS One, 2017.
  22. Huang BM et al. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biol Reprod, 2004.
  23. Zhang L et al. Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells. Reproduction, 2024.
  24. Mangold CA et al. Zombie ant death grip due to hypercontracted mandibular muscles. J Exp Biol, 2019.
  25. Kobmoo N et al. Population genomics revealed cryptic species within host-specific zombie-ant fungi (Ophiocordyceps unilateralis). Mol Phylogenet Evol, 2019.
  26. Robert VA, Casadevall A. Vertebrate endothermy restricts most fungi as potential pathogens. J Infect Dis, 2009.
  27. University of Calgary. UCalgary biologist says fungus presents no Last of Us-style threat to humanity. 2023.
  28. Memorial Sloan Kettering Cancer Center. Cordyceps.
  29. WebMD. What is cordyceps?
  30. MedicineNet. Cordyceps.
  31. Department of Health and Social Care. Great Britain nutrition and health claims (NHC) register.
  32. National Cancer Institute. Medicinal mushrooms (PDQ).

Written by

Co-founder, Evopure

Martin co-founded Evopure and writes about sleep, stress and recovery. Our articles are general information, not medical advice.

Questions, answered

It's mainly taken for energy and exercise. Small trials found modest improvements in exercise capacity in older or less-trained adults, but not in trained athletes.

None are proven to a high standard. The best human evidence is small trials showing modest changes in exercise capacity and immune blood markers. There are no authorised health claims for cordyceps in Great Britain.

For most healthy adults, short-term use at 1 to 3g a day appears well tolerated. Avoid it in pregnancy and breastfeeding, and check with your GP if you take blood thinners, diabetes medicines or immunosuppressants.

No official dose exists. Trials used about 1g to 4g a day, and 1 to 3g is typical. Follow the label, as extract strengths vary.

In the morning or 30 to 60 minutes before exercise, with food if it upsets your stomach. Many people avoid taking it in the evening.

There are no head-to-head trials. Militaris is usually more affordable and higher in cordycepin; CS-4 has more of the older research.

It has raised testosterone in mice, but this hasn't been shown in people. If you're worried about low testosterone or libido, see your GP.

Trials in people with COPD reported possible improvements, but none were placebo-controlled or high quality. If you have a lung condition, talk to your GP or specialist before trying it.

A Cochrane review of trials in people with chronic kidney disease found some better test results when cordyceps was added to usual treatment, but the studies were poor quality. If you have kidney disease, don't take it without your kidney team's advice.

One tiny trial found faster reaction times after a single dose and hard exercise. Claims about memory come from animal studies.

We found no human trials of cordyceps supplements for skin or hair growth. One trial tested a skin cream containing cordyceps extract for melasma, used alongside a prescription tablet.

There's little human evidence. Reishi is the mushroom more often used for evening calm.

No. Cordyceps contains no psilocybin and has no psychoactive effects.

No. Cordyceps and its relatives infect insects, and most fungi can't grow at human body temperature of about 37°C. The zombie fungus in The Last of Us is fiction.

Not quite. Wild Cordyceps sinensis is a rare, expensive caterpillar fungus. CS-4 is mycelium grown by fermentation, and its original strain has been identified as a related fungus, Paecilomyces hepiali. Most supplements sold as sinensis are fermented mycelium.

None are proven. One small Thai trial found higher natural killer cell activity in women after 8 weeks, and fertility and hormone claims rest on lab cell studies. Avoid it in pregnancy and breastfeeding, with autoimmune conditions, and check first if you take blood thinners.

Partly. The show's fungus is fictional, but zombie-ant fungi such as Ophiocordyceps unilateralis really do control carpenter ants. They're specific to insects and can't grow at human body temperature.

Ask your vet first. Our products are for adults only and not for pets.

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