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CBD vs THC: Key Differences, UK Law, Drug Tests and Driving

CBD and THC are both cannabinoids from the cannabis plant, but THC makes you high and CBD doesn’t.

CBD vs THC:  6 Differences You Should Know!

Last updated: October 2026

CBD and THC are both cannabinoids from the cannabis plant, but THC makes you high and CBD doesn’t. In the UK, THC is a controlled Class B drug, while CBD is legal in food supplements that meet the rules. THC also impairs driving and shows up on drug tests.

Below: a side-by-side comparison, why two molecules with the same formula act so differently, effects and side effects, the UK’s 1mg THC rule, drug tests, the driving limit, other cannabinoids such as THCA and CBN, and how to avoid THC.

CBD vs THC at a glance

CBD (cannabidiol) THC (tetrahydrocannabinol)
Gets you high? No Yes
UK legal status Legal in compliant food supplements Controlled, Class B
Addictive? No evidence of abuse potential Can cause dependence
Driving Didn’t impair driving in a 2020 trial; avoid if drowsy Impairs driving; illegal above a very low blood limit
Drug tests Not usually tested for The main thing tests look for
Main source Hemp Drug-type cannabis

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Same formula, different shape

CBD (cannabidiol) and THC (delta-9-tetrahydrocannabinol) are built from exactly the same atoms: 21 carbon, 30 hydrogen and 2 oxygen, written C21H30O2. The difference is how those atoms are arranged. In THC, part of the molecule closes into an extra ring; in CBD that ring stays open.

That small change alters how each one fits the body’s cannabinoid receptors, which is why one is intoxicating and the other isn’t. In the living plant, THC starts out mostly as an acid, THCA, which breaks down into THC over time and with heat. For how hemp seed oil differs from both, see hemp oil vs CBD oil.

How they affect you

THC strongly activates CB1 receptors in the brain, which causes the high, changes in perception, appetite and memory, and sometimes anxiety or paranoia. FRANK warns that regular cannabis use can lead to dependence and, in some people, mental health problems. CBD binds only weakly to CB1 and acts on several other targets, so it doesn’t change your state of mind. In trials, even large doses of CBD felt like a placebo. See does CBD get you high?, what CBD feels like and the endocannabinoid system.

In pharmacology terms, THC is a partial agonist at the CB1 and CB2 receptors: it switches them on, though not fully. In lab studies CBD behaves quite differently, and can block other compounds from switching those receptors on rather than activating them itself. For what the research does and doesn’t show for CBD on its own, see CBD and anxiety and CBD for pain.

Side effects compared

THC’s side effects come mostly from the high itself. CBD’s are usually milder and more physical, and in trials they were mostly seen at doses far above supplement levels.

Side effect CBD THC
Feeling high No Yes
Anxiety or paranoia Not a typical effect Can happen, especially with a lot
Physical effects Tiredness, diarrhoea, appetite changes Hunger, drowsiness, feeling sick
Dependence No abuse signal in a 2017 study Cravings and withdrawal in heavy users

CBD can also interact with some medicines, so check with your GP or pharmacist first if you take any. See CBD side effects for what’s normal and who should avoid CBD, and our CBD dosage guide for how much to take.

CBD vs THC for sleep

Neither is an approved sleep aid in the UK. THC can make people drowsy in the short term, but it changes the shape of your sleep, wears off with regular use and often disturbs sleep when you stop. CBD on its own hasn’t shown a clear effect on sleep in controlled trials. Here’s what the research actually says.

THC and sleep

Many people find THC sedating. Older sleep-lab studies found that a dose of cannabis or THC shortened the time it took to fall asleep and reduced REM sleep, the stage in which most dreaming happens. The catch is what happens next. Repeated use builds tolerance, including to THC’s effects on sleep, and a 2017 review concluded that THC could impair sleep quality over the long term.

Stopping after regular, heavy use is often hard on sleep. A systematic review of cannabis withdrawal studies found sleep was frequently interrupted, and sleep-lab studies of heavy users have recorded less total sleep and less REM sleep during abstinence.

CBD and sleep

The evidence for CBD alone is small and mixed. In a 2018 placebo-controlled sleep-lab trial, a single 300mg dose of CBD made no measurable difference to the sleep of healthy volunteers. A 2025 meta-analysis of six randomised trials found that CBD-only products had no significant effect on self-rated sleep quality, while products containing THC or other cannabinoids scored better. A 2020 systematic review found there wasn’t enough evidence to support routine use of any cannabinoid for any sleep disorder.

Trial doses are also far higher than the FSA’s precautionary advice of 10mg a day: 300mg is 30 times that figure. CBD supplements have no authorised health claims, and CBD isn’t a treatment for insomnia or any other sleep problem.

THC CBD on its own
Short-term effect in studies Often drowsy; may fall asleep faster No clear effect on sleep in a 300mg sleep-lab trial
Sleep stages Less REM (dreaming) sleep No change to normal sleep stages in that trial
With regular use Tolerance builds; sleep quality may suffer Few long-term studies
Stopping Sleep often disrupted during withdrawal No sign of abuse potential in a 2017 study
UK legal status Class B drug; not prescribed for insomnia Legal in compliant food supplements; not a sleep treatment

What UK law allows

THC is a Class B drug, so there is no legal way to buy it for sleep. On the NHS, cannabis-based medicines can only be prescribed by a specialist hospital doctor, for a small number of conditions: rare, severe forms of epilepsy, sickness caused by chemotherapy and muscle stiffness in multiple sclerosis. Insomnia isn’t one of them. The NHS also warns that cannabis products sold online without a prescription are likely to be illegal and have a good chance of containing THC.

CBN (cannabinol), often marketed abroad as a sleep cannabinoid, is a Class B drug too, according to the Home Office. Gummies, vapes and oils made to contain THC or CBN are controlled in the UK, whatever the label says.

If poor sleep is affecting your days, your GP is the place to start, and our guide to insomnia covers what the NHS recommends. For a closer look at the studies, read what the research says about CBD and sleep. If you’d like CBD as part of your evening routine, our guide to the best CBD oil for sleep explains how to choose one.

Drug tests and driving

  • Drug tests look for THC and its breakdown products, not CBD. A CBD product containing traces of THC could still cause a positive result. See CBD and drug tests.
  • Driving: it’s illegal to drive with certain levels of illegal drugs, including cannabis, in your blood, even if your driving seems fine. Police can use roadside kits that screen for cannabis. A 2020 on-road trial found CBD-dominant cannabis didn’t impair driving, while THC did. Don’t drive if any product makes you drowsy. See CBD and driving.

How much THC does it take to fail a test?

Less than you might think. In a 2026 US trial, 60 adults took 100mg of CBD in MCT oil containing between 0 and 3.7mg of THC. After a single dose, at least one person in every group taking 1mg of THC or more failed a urine test. Over two weeks of twice-daily use, there were positive tests in every group whose oil contained any THC, even 0.5mg, and one sample in the CBD-only group also tested positive. An earlier study found that single 100mg doses of pure CBD didn’t produce a confirmed positive result.

Standard tests can’t tell whether THC came from a legal hemp product or from cannabis. If you are tested at work or in sport, a broad spectrum or isolate product with a batch report showing THC as not detected is the safer choice.

The THC driving limit

In England and Wales, the legal limit for driving is 2 micrograms of THC per litre of blood, and Scotland uses the same figure. There is no limit for CBD. A drug-driving conviction means a minimum one-year driving ban, an unlimited fine, up to 6 months in prison and a criminal record. FRANK warns that driving when high can double your chances of a serious or fatal crash.

Medicines that use CBD and THC

Medicine Contains Licensed in the UK for
Epidyolex Purified CBD Seizures in some rare forms of epilepsy
Sativex THC and CBD spray Muscle spasticity in multiple sclerosis
Nabilone A synthetic THC-like drug Nausea from chemotherapy

These are prescription medicines at much higher doses than supplements. See medical cannabis UK and prescription CBD.

Other cannabinoids: THCA, CBN, CBG, delta-8 and THCV

CBD and THC are only two of many cannabinoids in cannabis. Here is how some others you may see sold online compare in UK law.

Cannabinoid What it is UK status
THCA The raw acid form of THC Pure THCA isn’t controlled, but it breaks down into THC (Class B)
CBN Forms as THC ages Class B
Delta-8 THC A close relative of THC Controlled: counts towards the 1mg rule
THCV A THC relative found in some strains Controlled: counts towards the 1mg rule
CBG Cannabigerol, sold much like CBD Not named in the Home Office factsheet; products must still meet the THC rules

Products sold as THCA flower, CBN gummies or delta-8 vapes carry real legal risk in the UK, whatever the label says. Read more in CBD vs CBN, what is THCV?, CBG vs CBD and delta-8 THC in the UK.

How to avoid THC

Full spectrum vs broad spectrum vs isolate

Type THC What else is in it
Full spectrum Small amounts Other cannabinoids and terpenes
Broad spectrum Removed to non-detectable levels Other cannabinoids and terpenes
Isolate None CBD only

More detail in CBD distillate vs isolate vs full spectrum.

CBD vs THC gummies, vapes and drinks

The difference is the same whatever the format. A legal CBD gummy, vape or drink in the UK contains CBD with no more than tiny traces of THC. Products sold as THC gummies, THC vapes or THC drinks are controlled drugs here, and the NHS warns that cannabis products bought online without a prescription have a good chance of containing THC. CBD food and drink must also be linked to the FSA public list.

Our CBD oils and capsules are broad spectrum with 0% THC, tested at ISO 17025 accredited labs (reports on request via our lab testing page) and on the FSA public list. Our Broad Spectrum CBD Oil is simply CBD in organic MCT oil. For help choosing, see best CBD oil UK. All our products are for adults (18+) only. The FSA’s 10mg a day figure is precautionary advice rather than a legal limit, set while longer-term safety research continues. At Evopure we think it is a very cautious figure, and many adults use more. If you go above it, increase slowly, and check with your GP or pharmacist first if you take any medication. We don’t recommend our products during pregnancy or breastfeeding.

For the full picture, see what is CBD? The complete UK guide.

Video: the difference between CBD and THC

A short explainer on how CBD and THC differ and what that means for you.

Noticed a racing heart after a CBD product? Read why CBD can cause palpitations (and why THC is often the real culprit).

See also how THC is removed during CBD extraction.

See also CBD vs Sativex for MS for how the THC and CBD spray compares with CBD supplements.

Related guides

Sources 22

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  2. Babalonis S et al. Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers. Drug Alcohol Depend, 2017.
  3. GOV.UK. Drugs and driving: the law.
  4. FRANK. Cannabis.
  5. legislation.gov.uk. Misuse of Drugs Act 1971, Schedule 2.
  6. NHS. Medical cannabis (and cannabis oils).
  7. Home Office. Drug licensing factsheet: cannabis, CBD and other cannabinoids. Updated 2024.
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  9. Kesner AJ, Lovinger DM. Cannabinoids, endocannabinoids and sleep. Front Mol Neurosci, 2020.
  10. Gates P et al. Cannabis withdrawal and sleep: a systematic review of human studies. Subst Abus, 2016.
  11. Linares IMP et al. No acute effects of cannabidiol on the sleep-wake cycle of healthy subjects: a randomized, double-blind, placebo-controlled, crossover study. Front Pharmacol, 2018.
  12. Suraev AS et al. Cannabinoid therapies in the management of sleep disorders: a systematic review of preclinical and clinical studies. Sleep Med Rev, 2020.
  13. da Silva GHS et al. Effectiveness of cannabinoids on subjective sleep quality in people with and without insomnia or poor sleep: a systematic review and meta-analysis of randomised studies. Sleep Med Rev, 2025.
  14. Iffland K, Grotenhermen F. An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies. Cannabis Cannabinoid Res, 2017.
  15. Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol, 2008.
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  17. Spindle TR et al. Urinary pharmacokinetic profile of cannabinoids following administration of vaporized and oral cannabidiol and vaporized CBD-dominant cannabis. J Anal Toxicol, 2020.
  18. Wolinsky D et al. The acute and chronic pharmacokinetics and pharmacodynamics of oral cannabidiol with and without low doses of delta-9-tetrahydrocannabinol. J Anal Toxicol, 2026.
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Written by

Haseeb Bani

Co-founder and formulation chemist, Evopure

Haseeb is a chemist who spent years formulating supplements before co-founding Evopure. Our articles are general information, not medical advice.

Questions, answered

THC is intoxicating and a controlled drug in the UK. CBD isn't intoxicating and is legal in compliant food supplements.

Full spectrum products contain some THC. Broad spectrum and isolate have THC removed to non-detectable levels. UK products may contain only tiny traces.

Tests look for THC, not CBD, but a product with traces of THC could cause a positive result.

CBD on its own didn't impair driving in a 2020 trial, but don't drive if you feel drowsy, and avoid products containing THC.

No. THC is a Class B drug. It's only available in specific prescription medicines.

Neither is a recommended sleep treatment in the UK. THC can cause short-term drowsiness, but it reduces REM sleep, loses its effect with regular use and often disrupts sleep when you stop. CBD on its own hasn't shown a clear effect on sleep in controlled trials. THC is also a Class B drug. For ongoing sleep problems, see your GP.

No. THC is a Class B drug. Cannabis-based medicines can only be prescribed on the NHS by a specialist hospital doctor for a few conditions, and insomnia isn't one of them. Products containing THC or CBN sold online are likely to be illegal.

CBD doesn't get you high or change your state of mind, and in trials even large doses felt similar to a placebo. It acts on several targets in the body, including the endocannabinoid system. Some people notice tiredness, an upset stomach or a change in appetite, and CBD can interact with some medicines, so check with your GP or pharmacist if you take any.

Neither is a treatment you can buy in the UK. THC can cause anxiety and paranoia, especially in large amounts, and it is a Class B drug. CBD supplements have no authorised health claims, and CBD isn't a treatment for anxiety or pain. On the NHS, cannabis-based medicines are prescribed only by specialists for a few conditions. If anxiety or pain is affecting your life, talk to your GP.

UK CBD products can contain controlled cannabinoids such as THC only if the product isn't designed to deliver them, they can't easily be recovered, and no one component part contains more than 1mg. The 1mg applies to the whole container, not a single dose.

2 micrograms of THC per litre of blood in England and Wales, and the same in Scotland. There is no limit for CBD, but don't drive if any product makes you drowsy.

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