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Does High Cholesterol Make You Tired? Real Causes and When to See a GP (UK)

High cholesterol doesn’t usually make you tired. The NHS says high cholesterol does not usually cause symptoms, and you can only find out you have it from a blood test.

Tired man in glasses with his hand on his forehead

Last updated: 10 November 2026

High cholesterol doesn’t usually make you tired. The NHS says high cholesterol does not usually cause symptoms, and you can only find out you have it from a blood test. If you’re tired and have high cholesterol, the cause is more often something that travels with it, such as statins, an underactive thyroid, type 2 diabetes or sleep apnoea.

If you’ve felt tired for a few weeks and aren’t sure why, see a GP. Checked against the NHS high cholesterol, cholesterol levels, NHS Health Check and tiredness pages, the British Thyroid Foundation and the British Heart Foundation in November 2026.

Can high cholesterol make you tired?

High cholesterol on its own is not a known cause of tiredness. Cholesterol is a fatty substance in your blood, and too much of it can block your blood vessels over time, raising the risk of heart attack and stroke. The NHS says it does not usually cause symptoms, which is why so many people only find out from a routine blood test.

So if you feel drained, it’s worth looking for the real cause rather than putting it down to your cholesterol number. These are the healthy levels the NHS gives for adults:

Cholesterol type (NHS) Healthy level for adults
Total cholesterol Below 5mmol/L
Non-HDL (“bad”) cholesterol Below 4mmol/L
HDL (“good”) cholesterol Above 1.0mmol/L for men or above 1.2mmol/L for women

The NHS says your own target depends on your age, other health conditions and your risk of heart disease, so ask your GP what your numbers mean for you. For how stress fits in, see does stress cause high cholesterol?

What else causes tiredness when you have high cholesterol?

Several common causes of tiredness either raise cholesterol or tend to turn up alongside it. A GP can check most of them with a blood test or a few questions.

Possible cause Link with cholesterol Does it cause tiredness?
Statins The main medicine for high cholesterol Yes: the NHS lists “feeling more tired or weaker than usual” as a common side effect
Underactive thyroid The British Thyroid Foundation lists raised cholesterol as a feature Yes: the NHS lists “feeling extremely tired (fatigue)”
Type 2 diabetes A GP may suggest a cholesterol test if you have diabetes Yes: “feeling very tired” is a common symptom
Sleep apnoea Linked with being overweight, like high cholesterol Yes: the NHS says you may “feel very tired” in the day
Being overweight The NHS lists it as a cause of high cholesterol Yes: the NHS lists “feeling very tired (fatigue)” with obesity
Alcohol The NHS lists drinking alcohol as a cause It breaks up sleep, so you wake less rested

Statins

If you started a statin and then felt tired, the medicine may be part of it: the NHS lists feeling more tired or weaker than usual, muscle pain and sleep problems among the common side effects. Never stop a statin on your own: your GP can change the dose or try a different one. See do statins make you tired? and, for the CoQ10 question, CoQ10.

Underactive thyroid

An underactive thyroid (hypothyroidism) slows the body down. The NHS lists tiredness, feeling cold, weight gain, constipation and low mood among its symptoms, and the British Thyroid Foundation lists raised cholesterol too. A simple blood test checks it. See underactive thyroid symptoms.

Type 2 diabetes

The NHS lists feeling very tired, peeing more than usual, feeling thirsty all the time and losing weight without trying as common symptoms, but says not everyone with type 2 diabetes has symptoms. See does diabetes make you tired?

Sleep apnoea and weight

Sleep apnoea is when your breathing stops and starts while you sleep. It’s linked with obesity and leaves you very tired in the day, and without treatment it can lead to high blood pressure and heart disease. If someone says you snore loudly or stop breathing at night, see sleep apnoea and a GP.

Low iron, low vitamin B12, poor sleep and low mood are other common causes worth ruling out. See iron deficiency symptoms, vitamin B12 deficiency and, for the bigger picture, why am I always tired?

Does familial hypercholesterolaemia cause tiredness?

No. Familial hypercholesterolaemia (FH) is an inherited condition that causes very high cholesterol from birth, but it doesn’t cause tiredness or usually any symptoms. The British Heart Foundation says it affects about 1 in 250 people, around 270,000 people in the UK, and many don’t know they have it.

Rarely, FH causes visible signs: lumps around the knuckles, knees or Achilles tendon, a pale white ring around the coloured part of the eye, or small yellow patches near the eyelids. If you’re diagnosed, the BHF says your parents, brothers and sisters and children should be checked too, because each has a 1 in 2 chance of having it. If heart disease runs young in your family, ask your GP about a test.

Can tiredness be a sign of heart problems?

Sometimes. Over years, high cholesterol can narrow the arteries and lead to coronary heart disease, whose most common symptoms the NHS gives as chest pain (angina) and breathlessness. Heart failure, which can follow long-term strain from coronary heart disease or high blood pressure, lists feeling weak, light-headed or very tired, particularly after moving, as a symptom.

Tiredness with breathlessness, chest pain or swollen ankles needs a GP appointment, not a wait-and-see. High blood pressure often sits alongside high cholesterol: see normal blood pressure and does high blood pressure make you tired?

How do I find out if I have high cholesterol?

With a blood test. The NHS says ask your GP surgery for a cholesterol test if you’ve not had one before and you’re over 40, overweight, or high cholesterol or heart problems run in your family. Most people don’t need to fast first. Some pharmacies offer tests too, but you may have to pay.

If you’re 40 to 74 and don’t already have heart disease, diabetes or a stroke, the free NHS Health Check includes a cholesterol test and a blood pressure test, and you should be invited every 5 years. If you’re tired as well, mention it: the GP may add other blood tests, such as thyroid, blood sugar and iron.

What to do if you’re tired with high cholesterol

  1. Don’t blame the number. Ask your GP to look for a cause of the tiredness, especially if it has lasted a few weeks.
  2. Keep taking your medicine. If you think a statin is making you tired, speak to your GP or pharmacist rather than stopping it.
  3. Move more. The NHS suggests at least 150 minutes of moderate exercise a week to help lower cholesterol, and regular activity tends to help energy too.
  4. Eat for your heart. The NHS advises less saturated fat (fatty meat, butter, cakes) and more oily fish, wholegrains, nuts, seeds, fruit and vegetables. See high fibre foods and omega 3.
  5. Cut back on alcohol and stop smoking. The NHS says not to regularly drink more than 14 units a week, and smoking can raise cholesterol. See alcohol and sleep.
  6. Protect your sleep. If you sleep 8 hours and still wake tired, see tired after 8 hours of sleep.

When to see a GP or get urgent help

If you have What to do
Tiredness for a few weeks with no clear reason, or tiredness that affects daily life See a GP
Tiredness with weight loss, mood changes, or loud snoring and gasping in your sleep See a GP
Tiredness you think is from a statin or another medicine Speak to your GP or pharmacist; don’t stop it on your own
Breathlessness lying down or during everyday activity, or sudden weight gain Urgent GP appointment or NHS 111
Chest pain that feels tight or squeezing, or spreads to your arms, neck or jaw, or severe difficulty breathing Call 999

Supplements with high cholesterol: check first

No supplement fixes tiredness caused by an illness or a medicine, and none replaces cholesterol treatment. If you take a statin or other regular medicines, tell your GP or pharmacist about any supplements or herbal remedies before you start them. Evopure doesn’t sell cholesterol medicines or cholesterol supplements.

CBD: we don’t suggest CBD for anyone taking regular medicines without advice. The FSA advises people taking any medication not to take CBD unless under medical direction. See can CBD interact with medication?

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Our Reishi Mushroom Adaptogenic Complex isn’t suggested here: its pack says it isn’t for people on medication. For how much magnesium adults need, see how much magnesium per day.

If you take any regular medicines, check with your GP or pharmacist first. We don’t recommend our products during pregnancy or breastfeeding. For adults (18+) only.

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Magnesium Glycinate Sleep Complex

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Subscribe and save 25% on your first order, then 20%. New to Evopure? Join our emails for 20% off a one-off first order. Free UK delivery over £45. If you take any regular medicines, check with your GP or pharmacist first. We don’t recommend our products during pregnancy or breastfeeding.

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Sources 9

  1. NHS. High cholesterol (reviewed 13 March 2026), Cholesterol levels, Getting tested and How to lower your cholesterol.
  2. NHS. NHS Health Check.
  3. NHS. Statins.
  4. NHS. Underactive thyroid, and British Thyroid Foundation. Hypothyroidism.
  5. NHS. Type 2 diabetes symptoms, Sleep apnoea and Obesity.
  6. British Heart Foundation. Familial hypercholesterolaemia.
  7. NHS. Coronary heart disease symptoms, Heart failure and Heart attack.
  8. NHS. Tiredness and fatigue.
  9. FSA (gov.uk). Cannabidiol (CBD) guidance.

This guide is general information, not medical advice. Always follow your GP and the leaflet that comes with your medicine. Evopure makes the Magnesium Glycinate Sleep Complex and doesn’t make or sell cholesterol medicines.

Written by

Co-founder, Evopure

Martin co-founded Evopure and writes about sleep, stress and recovery. Our articles are general information, not medical advice.

Questions, answered

Not usually. The NHS says high cholesterol does not usually cause symptoms. Tiredness is more often from something linked with it, such as statins, an underactive thyroid, type 2 diabetes, sleep apnoea or being overweight. See a GP if you've been tired for a few weeks.

Usually not. Most people feel completely well and only find out from a blood test. Over time it can lead to heart disease, which can cause chest pain and breathlessness, so feeling unwell with those symptoms needs a GP or, for severe chest pain, 999.

There usually aren't any. The only way to know is a blood test. People with inherited high cholesterol (familial hypercholesterolaemia) sometimes get lumps on the knuckles or Achilles tendon or yellow patches near the eyes, but these are rare.

Yes. The British Thyroid Foundation lists raised cholesterol among the features of an underactive thyroid, and the NHS lists extreme tiredness as a symptom. If you have both, ask your GP whether your thyroid has been checked.

They can. The NHS lists feeling more tired or weaker than usual as a common side effect. Don't stop a statin on your own: speak to your GP, who can change the dose or try a different statin.

For healthy adults the NHS gives total cholesterol below 5mmol/L, non-HDL cholesterol below 4mmol/L, and HDL cholesterol above 1.0mmol/L for men or above 1.2mmol/L for women. Your own target depends on your heart disease risk.

If you take a statin or any other regular medicine, speak to your GP or pharmacist first. The FSA advises people taking any medication not to take CBD unless under medical direction.

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