Last updated: 11 November 2026
CBD and blood pressure medication can be a tricky mix, so check before combining them. Small studies found high doses of CBD lowered blood pressure by around 5mmHg, which could add to your tablets and make you dizzy. CBD may also change how some heart medicines are processed. Ask your GP or pharmacist before starting CBD.
Below: what the research shows, common tablets one by one, dizziness on standing and when to get help. This is general information, not medical advice.
Can you take CBD with blood pressure medication?
Some people can, but check with your GP or pharmacist first. No study has tested CBD with common blood pressure tablets. The two concerns are that CBD may lower blood pressure a little on top of your medicine, causing dizziness, and that it may change levels of some heart medicines, such as propranolol or digoxin, through liver enzymes or a gut pump.
The Food Standards Agency (FSA) advises, as a precaution, that people taking any medication should not use CBD unless under medical direction. For the wider picture, see our guide to which medicines interact with CBD.
Does CBD lower blood pressure?
In a handful of small, short studies, high doses of CBD lowered blood pressure by a few points. The doses were 15 to 60 times the FSA’s 10mg a day advice, and in one trial the effect at rest faded within a week. CBD isn’t a treatment for high blood pressure.
| Study | Who | CBD dose | What happened |
|---|---|---|---|
| Jadoon 2017, UK | 9 healthy men | 600mg, single dose | Resting systolic pressure about 6mmHg lower; heart rate rose by up to 10 beats a minute |
| Sultan 2020, UK | 26 healthy men | 600mg a day for 7 days | Lower at rest after the first dose but not after 7 days; lower during stress throughout |
| Dragun 2023, Croatia | 16 adults with untreated high blood pressure | 150mg three times in 24 hours | 24-hour systolic pressure about 5mmHg lower |
| Dujic 2024, Croatia | 70 adults with high blood pressure, some on tablets | 225 to 450mg a day for 5 weeks | 24-hour systolic pressure about 5mmHg lower; no serious side effects reported |
The Croatian trials used a company’s patented CBD formulation and need repeating independently. On tablets, a further small drop could leave some people light-headed. See normal blood pressure by age. Asking about magnesium instead? See magnesium for blood pressure.
Blood pressure medicines and CBD: what is known
We found no studies of CBD with any of these medicines, so this table is based on how each is processed.
| Medicine type | Examples | How it is processed | Possible issue with CBD | What to do |
|---|---|---|---|---|
| Calcium channel blockers | Amlodipine, nifedipine, felodipine | CYP3A4 (grapefruit warning) | Big rise unlikely (CBD didn’t affect CYP3A4 in people); added dizziness possible | Ask a pharmacist |
| Beta blockers | Bisoprolol | Half by the liver (CYP3A4), half through the kidneys | Little enzyme effect expected. Tiredness and dizziness could add up | Ask a pharmacist |
| Beta blockers | Propranolol, metoprolol | CYP1A2, CYP2D6, CYP2C19 | CBD slows CYP1A2 and CYP2C19 in people, so propranolol levels could rise in theory | Ask your GP or pharmacist first |
| ACE inhibitors | Ramipril, lisinopril, perindopril | Not by CYP enzymes | Enzyme interaction unlikely; added lowering possible | Ask a pharmacist |
| ARBs | Losartan, candesartan | Losartan is activated by CYP2C9 and CYP3A4 | CBD slows CYP2C9 in lab tests, which could in theory change losartan’s effect | Ask a pharmacist |
| Diuretics and alpha blockers | Indapamide, bendroflumethiazide, doxazosin | Mixed | Dizziness on standing, especially when doxazosin is first started | Ask a pharmacist; stand up slowly |
| Digoxin | Digoxin | Carried by the gut pump P-gp | The Epidyolex product information says digoxin levels may rise | Ask your GP before using CBD |
Enzyme details come from each medicine’s product information. Taking a statin as well? See do statins make you tired?
Can you take CBD with amlodipine?
Ask a pharmacist first. Amlodipine is processed by CYP3A4, which is why its leaflet warns against grapefruit. CBD is often said to act like grapefruit, but in a study in healthy volunteers it made no difference to midazolam, the standard test for CYP3A4. So a large rise in amlodipine is unlikely; the more realistic issue is extra dizziness.
The NHS lists dizziness and sleepiness among amlodipine’s common side effects and advises limiting alcohol.
CBD with bisoprolol or propranolol
Bisoprolol is cleared half by the liver and half by the kidneys, so CBD is unlikely to change its levels much. Propranolol relies on several enzymes, including CYP1A2 and CYP2C19, both of which CBD slowed in studies in people at prescription doses. Neither combination has been studied.
iBeta blockers commonly cause tiredness, cold hands and dizziness, and CBD can cause sleepiness, so ask your GP or pharmacist first. More in do beta blockers make you tired?
CBD with ramipril or losartan
Ramipril and other ACE inhibitors aren’t processed by the CYP enzymes CBD affects, so an enzyme interaction is unlikely. Losartan is turned into its more active form partly by CYP2C9, which CBD blocks in lab tests, so its effect could change in theory. With both, any extra lowering of blood pressure is the thing to watch. Ask a pharmacist before starting CBD.
Dizziness when you stand up
A drop in blood pressure when you stand (postural hypotension) can make you dizzy or faint, and is more common in older adults on several medicines. The NHS advice:
- get up slowly, from lying to sitting to standing
- avoid standing still for long periods and bending down suddenly
- drink enough fluids, and go easy on alcohol
- check your blood pressure at home for the first couple of weeks and keep a note to show your GP
See our guides to low blood pressure and, if tiredness is the problem, does high blood pressure make you tired? If you notice a racing heart, read can CBD cause heart palpitations?
Does the amount of CBD matter?
Yes. The blood pressure studies used 150 to 600mg of CBD at a time, and the enzyme findings came from doses up to 1,500mg a day, against the FSA’s 10mg a day advice. A 2023 review suggested relevant interactions are likely only above about 300mg a day, but supplement amounts haven’t been tested. See our CBD dosage guide.
What to ask your GP or pharmacist
Take your medicine list and the CBD product, or a photo of its label, and ask:
- Is CBD a reasonable idea with my blood pressure tablets, and at what amount?
- Should I check my blood pressure at home when I start, and what reading should prompt a call?
- What should I do if I feel dizzy when I stand?
Never stop or change a blood pressure medicine to make room for CBD. Other medicines too? See CBD and blood thinners, CBD and antidepressants and CBD for older adults.
When to get help
Call 999 if someone faints and can’t be woken within 1 minute, has chest pain or a pounding or irregular heartbeat, has difficulty speaking or moving, hurts themselves when they fall, or faints while lying down or exercising.
Stop CBD and call your GP or NHS 111 if you get severe or repeated dizziness, light-headedness or fainting, or your home blood pressure readings are much lower than usual.
For CBD’s own side effects, see CBD side effects.
If your GP or pharmacist says CBD is OK
The FSA’s 10mg a day figure is precautionary advice rather than a legal limit, set while longer-term safety research continues. At Evopure we think it is a very cautious figure, and many adults use more. If you go above it, increase slowly, and check with your GP or pharmacist first if you take any medication.
With blood pressure tablets, a small fixed amount taken at the same time each day makes any effect easy to spot on your home readings.
Next step
CBD Capsules Broad Spectrum
Only with your GP’s or pharmacist’s OK: Broad Spectrum CBD Capsules give a measured dose, one 10mg capsule, in a vegan capsule with 0% THC, alcohol-free and third-party lab tested. 30 capsules per jar.
Add Broad Spectrum CBD Capsules 10mg to bag or choose another strength
Subscribe and save 25% on your first order, then 20%. New to Evopure? Join our emails for 20% off a one-off first order. Free UK delivery over £40. The FSA advises healthy adults to take no more than 10mg of CBD a day: one 10mg capsule gives 10mg. Adults only. If you take blood pressure tablets or any other medicine, check with your GP or pharmacist first. We don’t recommend our products during pregnancy or breastfeeding.
Subscribe from £18.74One-off from £24.99
View productSources 10
- emc. Epidyolex 100 mg/ml oral solution: summary of product characteristics (sections 4.5 and 5.2). Revised June 2026.
- Jadoon KA et al. A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI Insight, 2017.
- Sultan SR et al. The effects of acute and sustained cannabidiol dosing for seven days on the haemodynamics in healthy men: a randomised controlled trial. Br J Clin Pharmacol, 2020.
- Dragun T et al. The influence of oral cannabidiol on 24-h ambulatory blood pressure and arterial stiffness in untreated hypertension. Adv Ther, 2023.
- Dujic G et al. Chronic effects of oral cannabidiol delivery on 24-h ambulatory blood pressure in patients with hypertension (HYPER-H21-4). Cannabis Cannabinoid Res, 2024.
- Herdegen T, Cascorbi I. Drug interactions of tetrahydrocannabinol and cannabidiol in cannabinoid drugs. Dtsch Arztebl Int, 2023.
- NHS. Amlodipine.
- NHS. Low blood pressure (hypotension).
- NHS. Fainting.
- Food Standards Agency (GOV.UK). Cannabidiol (CBD) guidance.
