How Do Mushrooms for Anxiety Work?

Although the exact mechanisms aren’t fully understood, research suggests that certain compounds found in mushrooms interact with neurotransmitters like serotonin and dopamine—the same chemicals responsible for regulating mood, focus, and stress responses.

Serotonin—often called the “feel-good” neurotransmitter—plays a major role in mood, appetite, and sleep regulation. Low levels are often linked to increased anxiety.

Dopamine—known as the “reward” neurotransmitter—supports motivation, attention, and emotional regulation. Insufficient dopamine has been associated with anxiety and depression.

When certain mushroom compounds bind to or influence these neurotransmitters, they may help stabilise mood and reduce anxiety symptoms. For example, psilocybin—found in specific (psychedelic) mushroom species—acts on serotonin receptors and has been studied for its strong anxiolytic (anti-anxiety) effects in clinical settings.

Beyond neurotransmitter activity, many medicinal mushrooms are rich in antioxidants and have anti-inflammatory properties. Since chronic inflammation and oxidative stress are increasingly recognised as contributors to anxiety and depression, reducing these may offer indirect mental health benefits.

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The Best Mushrooms for Anxiety

Not all mushrooms are created equal when it comes to supporting a calmer mind. Adaptogenic mushrooms—rich in beta-glucans, polysaccharides, and terpenoids—are particularly prized for their ability to help the body adapt to stress and maintain balance.

1) Reishi Mushroom (Ganoderma lucidum)

Known as the “Mushroom of Immortality,” Reishi has been used in traditional Chinese medicine for thousands of years to promote relaxation, reduce stress, and support restful sleep.

Reishi’s potential anti-anxiety benefits are believed to come from its anti-inflammatory and antioxidant compounds, which help counter oxidative stress and inflammation in the brain—both linked to mood disorders.

Scientific studies offer promising findings:

• Animal research found that Reishi extracts increased time spent in anxiety-reducing environments during behavioural tests.
• Human studies on participants with neurasthenia (stress-related fatigue and anxiety) showed significant improvements after 1,800mg of Reishi extract, three times daily for eight weeks.

Reishi mushrooms contain anti-inflammatory and antioxidant properties that may help relieve anxiety.

Read more: Guide to Reishi mushrooms

2) Lion’s Mane Mushroom (Hericium erinaceus)

Best known for its brain-boosting benefits, Lion’s Mane also shows promise as a natural mood stabiliser. It supports the production of nerve growth factor (NGF), a protein that helps maintain and repair neurons, potentially improving cognitive function and emotional balance.

Compounds in Lion’s Mane—hericenones and erinacines—have been found to support healthy brain function and may prevent age-related cognitive decline, both of which can help reduce anxiety symptoms.

Like Reishi, Lion’s Mane exhibits anti-inflammatory and antioxidant activity. Chronic inflammation can disrupt neurotransmitter signalling and elevate stress hormones like cortisol; reducing it may support calmer moods.

Research also suggests Lion’s Mane may increase serotonin and dopamine levels in the brain, which could contribute to its uplifting, anxiety-reducing effects.

Lion’s Mane may help relieve anxiety by increasing dopamine and serotonin levels in the brain.

3) Cordyceps Mushroom (Cordyceps militaris / sinensis)

Although famous for boosting energy and endurance, Cordyceps also possesses impressive stress-relieving and anti-inflammatory qualities that may help alleviate anxiety.

It’s thought to do so by:

• Reducing inflammation in the brain, supporting neurotransmitter balance and emotional stability.
• Supporting energy metabolism and combating fatigue, which can exacerbate anxiety.
• Regulating cortisol (the stress hormone), helping the body maintain equilibrium under pressure.

Chronic inflammation is linked to neurotransmitter imbalances, higher cortisol levels, and even changes in brain structure (such as reduced hippocampal volume)—all of which are associated with anxiety and depression. Cordyceps’ ability to combat these underlying processes may make it a powerful natural ally for stress and mood support.

Cordyceps may provide anxiety relief by reducing inflammation in the brain.

How to Use Mushrooms for Anxiety

There are several easy ways to integrate mushrooms into your wellness routine:

• Capsules or tablets: Convenient and pre-dosed for daily use.
• Powders: Blend into smoothies, teas, or coffee for a nutrient-rich boost.
• Tinctures: Liquid extracts absorbed quickly under the tongue or in drinks.
• Functional beverages: Teas, lattes, and tonics formulated with adaptogenic mushrooms.

For best results, consistency is key. You can also combine mushrooms with other anxiety-management strategies such as exercise, mindfulness, and therapy.

Note: While early research is promising, more studies are needed to confirm efficacy and determine optimal dosing. Always consult your doctor before introducing new supplements—especially if you take medication or have a pre-existing condition.

Final Thoughts

Mushrooms are emerging as a natural way to help reduce anxiety and support emotional balance. Compounds like beta-glucans, polysaccharides, and terpenoids in adaptogenic species can help regulate mood-related neurotransmitters and calm the nervous system.

Reishi, Lion’s Mane, and Cordyceps are the most researched options for anxiety relief, each offering unique benefits. Whether enjoyed as teas, tinctures, or supplements, they can be a gentle addition to your overall wellness plan.

Always consult with a healthcare professional to ensure they’re safe for your individual needs.

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