Anxiety rates in the UK are higher than ever, and while therapy and medication are vital tools, more people are looking for natural, side-effect-free ways to support their nervous system day-to-day.
But the wellness aisle is confusing. With hundreds of bottles promising "calm," "zen," and "tranquillity," which ingredients actually work?
In this guide, we’ve cut through the marketing fluff to rank the top 5 evidence-based natural supplements for anxiety in 2025. Whether you suffer from racing thoughts, physical tension, or chronic stress, there is a specific tool for the job.
Note: Always consult your GP before starting new supplements, especially if you are on medication.
How we ranked these supplements
We judged these ingredients based on three criteria:
- Scientific Evidence: Is there actual research backing the claims?
- Safety Profile: Can they be taken daily with minimal side effects?
- Effectiveness: Do real users report a noticeable difference?
1. CBD Oil (Broad-Spectrum)
Best for: Overall nervous system balance, panic, and daily overwhelm.
How it works: CBD interacts with your body's Endocannabinoid System (ECS), which is responsible for regulating fear, stress, and mood. It doesn't just "mask" anxiety; it helps your body return to a state of balance (homeostasis).
Why it wins: Unlike many herbs which take weeks to work, CBD often provides relief within 30–60 minutes.
Our Pick: Evopure Flow CBD Oil (Formulated with added Ashwagandha & Maca for resilience).
Read more: CBD Oil for Anxiety: Does It Work?
2. Magnesium Glycinate
Best for: Physical tension, tight chest, restless muscles, and sleep.
How it works: Magnesium blocks the activity of more stimulating neurotransmitters and binds to calming receptors. It essentially tells your muscles and brain to "power down."
Why it wins: Up to 70% of people are deficient in magnesium. Fixing this deficiency often resolves that constant "on edge" physical feeling.
Our Pick: Evopure Magnesium Sleep Blend (A blend of Glycinate & Citrate).
3. Ashwagandha
Best for: Chronic stress, high cortisol, and burnout.
How it works: Ashwagandha is an adaptogen. It lowers cortisol levels (the stress hormone) and helps your body adapt to stress over time. It is less of a "quick fix" and more of a long-term resilience builder.
Effectiveness: Studies have shown significant reductions in cortisol levels after 60 days of use.
Note: In our Flow CBD Oil, we use an advanced ultrasonic extraction method to infuse active ashwagandha compounds directly into the MCT oil carrier for optimal absorption.
4. Passionflower
Best for: Racing thoughts, looping worries ("monkey mind"), and insomnia.
How it works: Passionflower boosts GABA levels in the brain. GABA is the "brakes" of the brain—it slows down the firing of neurons that cause racing thoughts.
Our Pick: We formulate our Sleep CBD Oil with Passionflower extract specifically to stop pre-sleep overthinking.
5. L-Theanine
Best for: Jitters, social anxiety, and focus without sedation.
How it works: Found naturally in green tea, L-Theanine promotes alpha brain waves—a state of "relaxed alertness." It’s great for daytime use because it calms you down without making you sleepy.
Can you take them together? (The "Anxiety Stack")
Yes. In fact, these supplements often work best when combined because they target different pathways.
The Ultimate Daily Protocol:
- Morning: Flow CBD Oil (contains CBD + Ashwagandha) for stress resilience.
- Afternoon: L-Theanine (via green tea) or a top-up of CBD if needed.
- Evening: Magnesium Blend + Sleep CBD Oil (contains Passionflower) for deep rest.
Frequently asked questions
What is the #1 best supplement for anxiety?
For immediate relief, CBD Oil is often rated highest by users. For long-term stress reduction, Ashwagandha is the gold standard. Most people benefit from using both.
How quickly do natural supplements work?
CBD and L-Theanine can work within 30–60 minutes. Magnesium can take a few days to replenish levels, and Ashwagandha typically takes 2–4 weeks to show full effects.
Are these safe to take with antidepressants?
If you are on SSRIs or other medication, always consult your doctor. St John's Wort (not listed here) interacts with many meds, but CBD and Ashwagandha can also have interactions.
Do gummies work as well as oil?
Generally, sublingual oils (drops under the tongue) absorb faster and more effectively than gummies, which have to pass through the digestive system.
Final thoughts
You don't have to "just live with" anxiety. By supporting your nervous system with the right nutrients—specifically Magnesium, CBD, and adaptogens—you can lower your baseline stress and feel more like yourself again.
